|First appearance||"The Tip of the Zoidberg" (6ACV18)|
Garfield syndrome is a disease that causes you to act like Garfield and skin color changing to orange along with black stripes. Fry once got infected with it (as well as with Simpsons jaundice and Muppet gangrene) after losing blood.
- It is a reference to the comic strip Garfield.
Fry: My body rejected your liver and now I've got Garfield syndrome. [Fry sighs.] I hate Mondays.